10.1080/15548627.2020.1822089 [DOI] [PMC free article] [PubMed] [Google Scholar] 294.Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O
Thus, under hypoxia, glutamine metabolism contributes significantly to maintaining redox balance by ensuring a continuous supply of NADPH, which in turn supports the regeneration of reduced glutathione (GSH) and other antioxidant systems (93)
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Therefore, metformin is able to decrease the release of pro-inflammatory factors by a reduction in the number of opportunistic pathogenic bacteria
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